Dihydrochlorid of diaminodioxyarsenobenzene.



in water, and solu 1 6,

" acid there can be repaired from it a dihy.=-.

UNITED STATES PATENT oFFioE.

PAUL EHRLICH- AND ALFRED BEBTHEIM, OF FBANKFOBT-ON-THE-MAIN, GERMANY,

ASSIGNOJRS T0 FABBWERKE 'VOBM. MEIS'IEB LUOIUS & BB'U'NING, OF HOCHST-QN- THE-MAIN, GERMANY, A CORPORATION OF GERMANY.

JSIHYDBOGHLOBID OF DIAMINODIOXYARSENOBENZENE.

1,116,398 No Drawing.

To. all whom it may concern:

Be it known that we, PAUL Ennmcn,

.M; D., professor of medicine, and ALFRED following is a specification.

By reducing the 3-amino-4-oxy-phenyl arsinic acid there is produced the 13-3- diamino 4 4 dioxyarsenobenzene which, when dry, forms a yellow powder, insoluble le in caustic soda lye.

By treating this product with hydrochloric drochlorid, which is very, valuableyfqr fli'rapeutical purposese especially remedy r syphilis rand other infectious diseases. "Thelsaid dih'ydrochlorid of the diamino- 'di'oxyarsenobenzene is a yellow powder,

' readily soluble .in water and methyl alcohol,

almost insoluble mother and acetone. From its aqueous solution the freebase is precipitated .by sodium. carbonate, or sodium acetafte and also by caustic soda lye, but it re-' dissolves readily in an excess ofthe latter. From the 'aqueoussolution of the dihydro- .chloridthere is pre ipitated by means of diluted sulfuric acid 1; e sulfate, whichis very The rocedure I 'hydroc orid may for instance be asfollows: 866*parts by weight oi powdered I Specification of Letters Patent.

Application filed November 13, 1911.

for manufacturing the di Patented N W. 10, 1914. Serial No. 860,119.

3-3 -diamino 4 4 dioxyarsenobenzene are stirred in 3000 parts of cold methylalcohol and there are then added 292 parts of an alcoholic solution of hydrochloric acid of 25% strength, whereby the base dissolves with formation of the dihydrochlorid. After filtration, this solution is preci itated by means of ten times its quantity 0 ether. The lightt-tyellow precipitate thus obtained is filtere o washed with ether and dried at a low temperature. I

Having now particularly described our invention, what We claim is:

As a new product, the dihydrjochlorid of the 3 3 diamino b -dioxyarsnobenzene, being a yellow powder readilg goluble in water and methyl-alcohol, alm t insoluble in ether and acetone, from the aduceus solu tion of which is precipitated byimeans of sodium carbonate, sodium acetate or caustic soda lye, the diaminodioxyarsenobenzene, which re-dissolves in an excess of the caustic soda lye, a (liificultlg soluble sulfate bein precipitated from t e aqueous solution 0 the dihydrochlorid by means'of-diluted sulfuric acid. V

In testimony whereof, we afiix our signatures in presence of two witnesses.

PAUL'EHRLICH. ALFRE D BERTHEIM. Witnesses:

JEAN Gnmm, Cam, Gntmn. 

